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  <xs:element id="xncr_The2023PlanMember" abstract="true" name="The2023PlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xncr_The2013And2023PlansMember" abstract="true" name="The2013And2023PlansMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xncr_The2013PlanMember" abstract="true" name="The2013PlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xncr_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAndEquityInstrumentsOtherThanOptionsOutstanding" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAndEquityInstrumentsOtherThanOptionsOutstanding" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="xncr_ReportableSegmentMember" abstract="true" name="ReportableSegmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xncr_ResearchAndDevelopmentPerProgramAxis" abstract="true" name="ResearchAndDevelopmentPerProgramAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="xncr_ResearchAndDevelopmentPerProgramDomain" abstract="true" name="ResearchAndDevelopmentPerProgramDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xncr_XmAb942XtendTL1AMember" abstract="true" name="XmAb942XtendTL1AMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xncr_XmAb819ENPP3XCD3Member" abstract="true" name="XmAb819ENPP3XCD3Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xncr_XmAb412TL1AXIL23p19Member" abstract="true" name="XmAb412TL1AXIL23p19Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xncr_XmAb541CLDN6XCD3Member" abstract="true" name="XmAb541CLDN6XCD3Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xncr_XmAb657CD19XCD3Member" abstract="true" name="XmAb657CD19XCD3Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xncr_PlamotamabCD20XCD3Member" abstract="true" name="PlamotamabCD20XCD3Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xncr_XmAb808B7H3XCD28Member" abstract="true" name="XmAb808B7H3XCD28Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xncr_OtherProgramsIncludingResearchAndEarlyStageMember" abstract="true" name="OtherProgramsIncludingResearchAndEarlyStageMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xncr_WindDownCostsOfTerminatedProgramsMember" abstract="true" name="WindDownCostsOfTerminatedProgramsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xncr_ResearchAndDevelopmentExpenseExternal" abstract="false" name="ResearchAndDevelopmentExpenseExternal" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="xncr_InternalResearchAndDevelopmentExpense" abstract="false" name="InternalResearchAndDevelopmentExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="xncr_AlexionMember" abstract="true" name="AlexionMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="xncr_LossContingencySettlementAgreementNumberOfInstallments" abstract="false" name="LossContingencySettlementAgreementNumberOfInstallments" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="xncr_LossContingencySettlementAgreementInstallmentPaymentAmount" abstract="false" name="LossContingencySettlementAgreementInstallmentPaymentAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="xncr_LossContingencySettlementAgreementPaymentPeriod" abstract="false" name="LossContingencySettlementAgreementPaymentPeriod" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="xncr_JohnR.DesjarlaisMember" abstract="true" name="JohnR.DesjarlaisMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
</xs:schema>
